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BCR-ABL1 Genetic Test A BCR-ABL1 genetic test uses a sample of blood or bone marrow to look for an abnormal gene called BCR-ABL1. This abnormal gene is involved in certain types of blood cancer. It's found in: Most people who have chronic myeloid leukaemia (CML), which is also called chronic granulocytic leukaemia or chronic myeloid leukaemia Some people who have certain types of acute lymphoblastic leukaemia (ALL) Some people with acute myeloid leukaemia (AML), but very rarely The abnormal BCR-ABL1 gene is made when two separate genes merge together and become one gene. Genes are short sections of DNA. DNA is made of long strands of material that carry information that controls what you look like and how your body works. DNA is packaged into structures in your cells called chromosomes. Normally, most of your cells have the same set of 23 pairs of chromosomes. The abnormal BCR-ABL1 gene is formed when pieces of chromosomes 9 and 22 break off and trade places. The broken piece of ch...